Explanation of terms used by DrugBank

CYP450 2C9 substrate ADMET Feature Prediction

Cytochrome P450 2C9 substrate

In DrugBank, the property CYP450 2C9 substrate refers to a drug or chemical that will undergo a chemical or metabolic reaction with the CYP450 2C9 enzyme to produce products or metabolites that are different from the original substrate.

The value and probability predicted for this property are determined using software developed by admetSAR 1. The predicted value can be either 'Substrate' or 'Non-substrate' and refers to whether the drug being discussed is or is not a CYP450 2C9 substrate, respectively. Finally, the predicted probability is a numerical value between 0 and 1 that represents the percentage probability of the aforementioned predicted value.


  1. Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, Lee PW, Tang Y: admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model. 2012 Nov 26;52(11):3099-105. doi: 10.1021/ci300367a. Epub 2012 Nov 1. [PubMed:23092397]