LogS is directly related to the water solubility of a drug and it is defined as a common solubility unit corresponding to the 10-based logarithm of the solubility of a molecule measured in mol/L. The solubility and logS of a drug can be divided in:
- Intrinsic solubility (log S 0) - solubility measured after equilibrium between the dissolved and solid state at a pH where the compound is neutral
- pH-dependent solubility - the solvation equilibrium is affected by the solution pH.1
In DrugBank, it is possible to find the [experimental] and [predicted] value of logS.
- ChemAxon [Link]