NAV

P-glycoprotein inhibitor I ADMET Feature Prediction

Synonyms:

  • MDR1 inhibitor
  • p-gp inhibitor I
  • pgp 1 inhibitor
  • pgp inhibitor 1
  • pgp inhibitor I

This describes a substance that inhibits P-glycoprotein I. P-glycoprotein (P-gp/MDR1), is one of the most clinically important transporters in the human body, and is encoded by the ABCB1/MDR1 gene 2. The inhibition of the p-glycoprotein I transporter may have various medical effects and serious effects on other drugs that are given.

DrugBank automatically retrieves information from the admetSAR database, using a table format to display various predicted properties of a drug under the "Predicted ADMET features" section of a drug entry 1. This database predicts the absorption, distribution, metabolism, excretion, and toxicity of drugs (ADMET). This database also identifies drugs as predicted p-glycoprotein I "inhibitors" or "non-inhibitors". In the example below, obtained from the Acetaminophen drug entry, this drug is classified as a p-glycoprotein I "non-inhibitor". Other drugs may be classified as "inhibitors".

References:

  1. Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, Lee PW, Tang Y: admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model. 2012 Nov 26;52(11):3099-105. doi: 10.1021/ci300367a. Epub 2012 Nov 1. [PubMed:23092397]
  2. Zhou SF: Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica. 2008 Jul;38(7-8):802-32. doi: 10.1080/00498250701867889 . [PubMed:18668431]