NAV

Renal organic cation transporter ADMET Feature Prediction

Synonyms:

  • OCT
  • renal cationic organic transporter
  • SLC22A

The renal organic cation transporter is important for the uptake or efflux of cationic drugs 3. Various subtypes of this transporter exist, which mediate the transport of organic cations in the kidney. Clinically significant drug interactions in the kidney have been attributed to the inhibition of renal organic cation transporters 4. It is therefore important to be aware of which drugs may be renal organic cation transporter inhibitors. This information can be found in the "Predicted ADMET features" section of a drug entry.

DrugBank automatically retrieves information from admetSAR database, using a table format to display various predicted properties of a drug. This database predicts the absorption, distribution, metabolism, excretion, and toxicity of drugs (ADMET) 1. One prediction made by admetSAR is whether a substance inhibits or does not inhibit the renal organic cation transporters, which may include transporters such as OCTN1, OCTN2, OCT1, OCT2, OCT3 2,3. Drugs are classified as "inhibitors" or "non-inhibitors" of these transporters.

References:

  1. Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, Lee PW, Tang Y: admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model. 2012 Nov 26;52(11):3099-105. doi: 10.1021/ci300367a. Epub 2012 Nov 1. [PubMed:23092397]
  2. Burckhardt G, Wolff NA: Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol. 2000 Jun;278(6):F853-66. doi: 10.1152/ajprenal.2000.278.6.F853. [PubMed:10836973]
  3. Motohashi H, Inui K: Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney. AAPS J. 2013 Apr;15(2):581-8. doi: 10.1208/s12248-013-9465-7. Epub 2013 Feb 22. [PubMed:23435786]
  4. Yin J, Wang J: Renal drug transporters and their significance in drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):363-373. doi: 10.1016/j.apsb.2016.07.013. Epub 2016 Aug 9. [PubMed:27709005]