Glossary

Explanation of terms used by DrugBank

CYP450 inhibitory promiscuity


In DrugBank, the property CYP450 inhibitory promiscuity refers to the capacity for a drug or chemical to bind to and decrease or diminish the activity of multiple different CYP450 isoform enzymes 1.

The value and probability predicted for this property are determined using software developed by admetSAR 2. The predicted value can be either 'High CYP Inhibitory Promiscuity' or 'Low CYP Inhibitory Promiscuity' and refers to whether the drug being discussed does or does not possess substantial CYP450 inhibitory promiscuity, respectively. Finally, the predicted probability is a numerical value between 0 and 1 that represents the percentage probability of the aforementioned predicted value.

References:

  1. Cheng F, Yu Y, Zhou Y, Shen Z, Xiao W, Liu G, Li W, Lee PW, Tang Y: Insights into molecular basis of cytochrome p450 inhibitory promiscuity of compounds. J Chem Inf Model. 2011 Oct 24;51(10):2482-95. doi: 10.1021/ci200317s. Epub 2011 Sep 14. [PubMed:21875141]
  2. Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, Lee PW, Tang Y: admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model. 2012 Nov 26;52(11):3099-105. doi: 10.1021/ci300367a. Epub 2012 Nov 1. [PubMed:23092397]